Xanternet Ophthalmic Gel 20 Single Dose Vials 0.4ml

XanterNet OPHTHALMIC GEL

Transparent sterile ophthalmic gel without preservatives containing sodium hyaluronate, xanthan gum and 0.3% netilmicin. product indicated for the dressing of wounds and abrasions of the ocular surface caused by traumatic events or following surgery. The use of Xanternet is specific for those patients in whom, in the opinion of the doctor, there is a risk of infection.
Contains two natural polymers: hyaluronic acid and xanthan gum. Applied in the conjunctival fornix, Xanternet mixes with the tear and forms a viscous and transparent bandage which, by reducing the friction caused by eye movements and blinking, protects the surface of the eye favoring the repair processes resulting from wounds or abrasions.
Xanternet also contains netilmicin, a broad spectrum aminoglycoside antibiotic useful for reducing the risk of bacterial infections.
The product does not contain preservatives.

Composition
Sodium hyaluronate; xanthan gum; netilmicin 0.3%; disodium phosphate dodecahydrate; monobasic sodium phosphate monohydrate; sodium citrate; purified water.

How to use
It is recommended to administer Xanternet in the conjunctival fornix at a dose of one drop 4 times a day, unless otherwise indicated by the doctor.
Instructions for Use:
1. Before use make sure that the single-dose container is intact.
2. Detach the single dose from the strip.
3. Grasp the single-dose container by the base and shake downwards.
4. Open by twisting the top and pulling.
5. Instill Xanternet without letting the tip of the container come into contact with the eye or any other surface.

Contraindications
Hypersensitivity to aminoglycosides or to the other components of the product.

Precautions for use
Prolonged use of topical antibiotics can lead to the growth of resistant microorganisms.
In the event that, after a reasonable period of time (5-7 days), the use of the Xanternet viscous bandage does not lead to an improvement in the clinical picture or if irritation or manifestations of hypersensitivity occur, the treatment must be suspended and the specialist consulted. .
In very early childhood, the product should be administered in cases of real need and under the direct supervision of the doctor.

Interactions with other drugs or products for ophthalmic use
No significant drug interactions have been reported with the ophthalmic use of Netilmicin. However, due to the physical properties of the gel, it is recommended not to administer other drugs or products for ophthalmic use within 60 minutes following the administration of Xanternet.
The simultaneous topical administration, especially if intracavitary, of other potentially nephrotoxic and ototoxic antibiotics can increase the risk of these effects.
An increase in the potential nephrotoxicity of some aminoglycosides has been reported following subsequent or concomitant administration, which should be avoided, of other potentially nephrotoxic substances, such as cisplatin, polymyxin B, colistin, viomycin, streptomycin, vancomycin, other aminoglycosides and some cephalosporins (cephaloridine) or potent diuretics such as ethacrynic acid and furosemide, for the repercussions on the kidney.
In vitro, the association of an aminoglycoside with a beta-lactam antibiotic (penicillins or cephalosporins) can cause significant reciprocal inactivation. Even when an aminoglycoside and a penicillin-like antibiotic were administered through two different routes, a reduction in the half-life or plasma levels of the aminoglycoside occurred in patients with renal insufficiency and in some patients with normal renal function.

Other interactions
The product has been shown to be compatible with the simultaneous use of therapeutic contact lenses after PRK surgery.
The use of other types of contact lenses is not recommended unless 60 minutes have passed since the application of Xanternet.

Pregnancy and breastfeeding
Preclinical studies attest to the absence of fetal toxicity with the topical administration of Netilmicin due to the poor systemic absorption of the product. However, during pregnancy it should be administered in cases of real need and under the direct supervision of the doctor.
Aminoglycosides are excreted in breast milk, therefore, it is not recommended to take them during breastfeeding.

Warnings
For topical ocular use only.
Keep out of reach of children.
The product should be used on the advice of a doctor.
Occasionally, mild and transient burning may occur.
Do not touch the end of the open container and do not put it in direct contact with the eye.
Each single-dose container must be used immediately after opening, any residue must not be reused.
Do not use Xanternet after the expiration date.
Do not use Xanternet if the container is open or damaged.
Do not use Xanternet if it is not transparent.
Administration of Xanternet to children or people with limited abilities must be done by a responsible adult.

storage
As Xanternet does not contain preservatives, each single-dose container should only be used immediately after opening.
After opening the sachet, the remaining single-dose containers should be used within 12 weeks.
Store at a temperature not exceeding 30 ° C.

Format
Pack of 20 single-dose containers.

CE mark registration number 0373

Cod. HA / NET GEL