Vivin 500mg Acetylsalicylic Acid Pain Reliever 20 Tablets

Headache and toothache, neuralgia, menstrual pain, rheumatic and muscle pain. Symptomatic therapy of feverish states and flu and cold syndromes.

Hypersensitivity to acetylsalicylic acid, salicylates and other components of the product, haemorrhagic diseases, gastropathies (eg: gastro-duodenal ulcer disease), asthma, hypophosphataemia, renal insufficiency. Last trimester of pregnancy. The use of this medicine is contraindicated in children and young people under the age of sixteen. Dose> 100 mg / day during the third trimester of pregnancy. History of gastrointestinal bleeding or perforation related to previous active treatments or history of recurrent peptic ulcer / haemorrhage (two or more distinct episodes of proven ulceration or bleeding). Cardiovascular safety of NSAIDs: severe heart failure.

1-2 tablets 2 - 3 times a day. Do not exceed the recommended doses: in particular elderly patients should follow the minimum dosages indicated above. The tablets should be swallowed with or without drink (water).

After three days of use at the maximum dose or after 5-7 days of continuous use, without noticeable results, consult your doctor. It is also advisable that patients with glucose-6-phosphate-dehydrogenase deficiency, chronic or recurrent gastric and intestinal disorders or impaired renal function be consulted with the doctor. If prolonged vomiting and profound drowsiness occur during treatment, discontinue administration. This medicinal product should not be used in children and young people under the age of 16. People over 70 years of age, especially in the presence of concomitant therapies, should use this medicine only after consulting a doctor. The product must be taken on a full stomach. Pre-operative use can hinder intraoperative haemostasis. The use of the drug is not recommended in women who intend to become pregnant. The administration of the product should be suspended in women who have fertility problems 'or who are undergoing investigation of fertility'. The use of the medicinal product should be avoided in conjunction with selective COX-2 inhibitory NSAIDs. Undesirable effects can be minimized by using the lowest effective dose for the shortest possible duration of treatment needed to control symptoms. Elderly: Elderly patients have an increased frequency of adverse reactions to NSAIDs, especially gastrointestinal bleeding and perforation, which can be fatal. Gastrointestinal bleeding, ulceration and perforation: Gastrointestinal bleeding, ulceration and perforation, which can be fatal, have been reported during treatment with all NSAIDs, at any time, with or without warning symptoms or a previous history of serious gastrointestinal events. In the elderly and in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation, the risk of gastrointestinal bleeding, ulceration or perforation is higher with increasing doses of NSAIDs. These patients should start treatment with the lowest available dose. Concomitant use of protective agents (misoprostol or proton pump inhibitors) should be considered for these patients and also for patients taking low doses of aspirin or other drugs that may increase the risk of gastrointestinal events. Patients with a history of gastrointestinal toxicity should report any unusual gastrointestinal symptoms. Caution should be exercised in patients taking concomitant medications that could increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors or antiplatelet agents such as aspirin. When gastrointestinal bleeding or ulceration occurs in patients taking the drug, treatment should be discontinued. NSAIDs should be administered with caution to patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease) as these conditions may be exacerbated. Cardiovascular safety of NSAIDs Caution should be exercised in patients with a history of hypertension and / or heart failure as fluid retention and edema have been reported in association with NSAID therapy. Skin safety NSAIDs: Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs. In the early stages of therapy, patients appear to be at higher risk: the onset of the reaction occurs in most cases within the first month of treatment. The drug should be discontinued at the first appearance of skin rash, mucosal lesions or any other sign of hypersensitivity '. Caution is required (discuss with your doctor or pharmacist) before starting treatment in patients with a history of hypertension and / or heart failure as fluid retention, hypertension and edema have been reported in association with treatment with NSAIDs. Undesirable effects can be minimized by using the lowest effective dose for the shortest possible duration of treatment needed to control symptoms. Cardiovascular and cerebrovascular effects: Clinical studies and epidemiological data suggest that the use of some NSAIDs (especially at high doses and for long-term treatments) may be associated with a modest increased risk of arterial thrombotic events (e.g. heart attack heart disease or stroke). There are currently insufficient data to exclude a similar risk for acetylsalicylic acid when it is administered at a daily dose of 1-2 tablets 2 - 3 times a day.

The administration of acetylsalicylic acid, especially in the case of prolonged therapy, can enhance the activity of anticoagulant drugs (for example coumarin derivatives and heparin), the undesirable effects of methotrexate, the risk of gastrointestinal bleeding in case of simultaneous treatment with corticosteroids , the effects and secondary manifestations of all non-steroidal antirheumatics, the effect of blood glucose-lowering drugs (sulphonylurea). Precaution should be observed for substances such as spironolactone, furosemide and antigout preparations, whose activity is instead reduced by acetylsalicylic acid. Therefore, unless otherwise prescribed, the medicine should not be administered concomitantly with the above preparations. It is however advisable not to administer other drugs by mouth within 1 or 2 hours of using the product. Corticosteroids: increased risk of gastrointestinal ulceration or bleeding. Anticoagulants: NSAIDs can increase the effects of anticoagulants, such as warfarin. Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding. Diuretics, ACE inhibitors and angiotensin II antagonists: NSAIDs may reduce the effect of diuretics and other antihypertensive drugs. In some patients with impaired renal function (e.g. dehydrated patients or elderly patients with impaired renal function) the co-administration of an ACE inhibitor or angiotensin II antagonist and agents that inhibit the cyclo-oxygenase system may lead to further deterioration of renal function, including possible acute renal failure, usually reversible. These interactions should be considered in patients taking the drug concomitantly with ACE inhibitors or angiotensin II antagonists. Therefore, the combination should be administered with caution, especially in elderly patients. Patients should be adequately hydrated and monitoring of renal function should be considered after initiation of concomitant therapy.

During the course of treatment, gastric disturbances (pains, etc.) may occur, mostly in sensitive patients. In completely sporadic cases and in predisposed patients, bleeding episodes may occur (epistaxis, gingivorrhagia, gastrointestinal bleeding, etc.); hypersensitivity reactions may occur rarely, such as bronchial spasms, skin manifestations, oto-vestibular disturbances (buzzing) and, in extremely rare cases, reduction of platelets (thrombocytopenia) and delay in childbirth. Gastrointestinal: the most commonly observed adverse events are gastrointestinal in nature. Peptic ulcers, gastrointestinal perforation or bleeding, sometimes fatal, may occur, particularly in the elderly. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn's disease have been reported after administration of the drug. Gastritis has been observed less frequently. Cardiovascular safety of NSAIDs: Edema, hypertension and heart failure have been reported in association with NSAID treatment. Skin safety of NSAIDs: Bullous reactions including Stevens Johnson Syndrome and toxic epidermal necrolysis (very rarely). Edema, hypertension and heart failure have been reported in association with NSAID treatment. Clinical studies and epidemiological data suggest that the use of some NSAIDs (especially at high doses and for long-term treatments) may be associated with a modest increased risk of arterial thrombotic events (e.g. myocardial infarction or stroke). .

For use in breastfeeding and pregnant women consult your doctor. Do not use in the last three months of pregnancy unless the use is specifically prescribed by the doctor, since acetylsalicylic acid can cause haemorrhagic phenomena in the fetus and mother, delay in childbirth, and in the unborn child, early closure of the duct. Botallo. Low doses (up to 100 mg / day): doses up to 100 mg / day can be considered safe limited to use in obstetrics, which requires specialist monitoring. Doses of 100-500 mg / day: there are insufficient clinical data regarding the use of doses above 100 mg / day up to 500 mg / day. Therefore, the recommendations below for doses of 500 mg / day and above also apply to this dose range. Doses of 500 mg / day and over: inhibition of prostaglandin synthesis can negatively affect pregnancy and / or embryo / fetal development. Results of epidemiological studies suggest an increased risk of miscarriage and cardiac malformation and gastroschisis after use of a prostaglandin synthesis inhibitor in early pregnancy. The absolute risk of cardiac malformations was increased from less than 1% to approximately 1.5%. It has been estimated that the risk increases with dose and duration of therapy. In animals, administration of prostaglandin synthesis inhibitors has been shown to cause an increase in pre- and post-implantation loss and embryo-fetal mortality. Furthermore, an increased incidence of various malformations, including cardiovascular, has been reported in animals administered prostaglandin synthesis inhibitors during the organogenetic period. During the first and second trimester of pregnancy, acetylsalicylic acid should not be administered except in strictly necessary cases. If acetylsalicylic acid is used by a woman attempting to conceive, or during the first and second trimester of pregnancy, the dose and duration of treatment should be kept as low as possible. During the third trimester of pregnancy, all prostaglandin synthesis inhibitors can expose the fetus to: cardiopulmonary toxicity (with premature closure of the arterial duct and pulmonary hypertension); renal dysfunction, which can progress to renal failure with oligo-hydroamnios; the mother and the newborn, at the end of pregnancy, to: possible prolongation of the bleeding time, and antiplatelet effect which can occur even at very low doses; inhibition of uterine contractions resulting in delayed or prolonged labor. Consequently, acetylsalicylic acid at doses> 100 mg / day is contraindicated during the third trimester of pregnancy.