Podoker 40 Keratolytic Action Gel 30ml Tube With Applicator

PODOKER 40 ^GEL

Gel with keratogulatory action and / or
controlled keratolytics for treatment
podiatry of hyperkeratosis of the skin tissues
and in the thickening of the nail plate

Hyperkeratosis:
the symptom of a multisystemic and multifactorial phenomenon that requires a multiple and synchronic intervention

1 at the dermal level, controlling as much as possible the reactivity of the district mast cell;

ADELMIDROL COMPLEX / HYALURONIC ACID
Adelmidrol is the alamide able to control, when applied topically and made "bioadhesive" by hyaluronic acid, the hyperactivity of the district mast cell.

2 at the intermediate level, optimizing the differentiation of keratinocytes;

TOCOPHEROL / RETINOL COMPLEX
The Tocopherol / Retinol complex guarantees the optimization of the keratinization process of the keratinocytes.

3 at the level of the superficial layers of the skin, causing keratoregulation or inducing keratolysis, in order to limit the accumulation of low vitality keratinocytic cells.

UREA / GLYCERINE COMPLEX
Urea determines a progressive controlled breakdown of keratin, while Glycerin guarantees the right degree of superficial humidification of the treated skin.

Hyperkeratosis and dryness of the skin of the foot are the most evident symptoms of a multisystemic and multifactorial phenomenon in turn conditioned by the multiple endogenous (aging, dysmetabolic diseases) and / or exogenous (mechanical, chemical, physical) stresses to which an organ as complex as the foot must continually adapt.

In fact, different district systems such as the vascular, the nervous (both somatic and autonomic), the immune system participate in this phenomenon.

Intersystem regulation is managed by the district mast cell which acts as a real "orchestra conductor" of the homeostatic tissue balance. The mast cell, in fact, controls the permeation of water from the microcirculation, the activation and convergence of keratinocytes, the recruitment and activation of fibroblasts and therefore the normal organization of collagen, the regulation of the "pain threshold" (peripheral sensitization) , the keratinization process and trans dermal water loss (TEWL - Trans Epidermal Water Loss).

In situations of mast cell dysregulation, hyperkeratosis and dryness symptoms evolve towards stages of greater severity such as epidermal crack (classic is that of the heel) up to ulcerative lesions of the lower limbs.

It is therefore evident that to modify this symptomatology in a causal (and not only symptomatic) way, it is necessary to intervene on at least three different parameters, necessarily in a synchronic manner.

GEL with controlled keratolytic action
for the treatment of hyperkeratosis
severe skin tissues of the
foot (e.g. heel hyperkeratosis)
and thickening of the nail plate.

PODOKER 40 GEL acts on
intercellular matrix loosening
the stratum corneum of the tissues and facilitating,
thereby, exfoliation e
the softening of areas with high
hyperkeratotic thickness.

UREA 40%
Adelmidrol
Tocopherol
Retinol

Format
30 ml tube

Cod. 4074