Ntr*Nasal spray 15ml

NAME
NTR

PHARMACOTHERAPEUTIC CATEGORY
Nasal decongestants and other topical preparations.

ACTIVE PRINCIPLES
One ml contains: phenylephrine hydrochloride 5,000 mg, tenildiamine hydrochloride 1,000 mg, benzalkonium chloride 0.200 mg.

EXCIPIENTS
Buffered aqueous solution consisting of: sodium citrate 2H2O; sodium chloride; 2-phenoxyethanol; citric acid; purified water.

INDICATIONS
To relieve excessive secretion due to colds.

CONTRAINDICATIONS / SECONDARY EFFECT
Hypersensitivity 'to the active ingredients, or to any of the excipients; severe heart disease and high blood pressure; glaucoma, hyperthyroidism. Do not use the product in children under 12 years of age. Do not administer during and in the two weeks following antidepressant drug therapy. Do not administer during pregnancy and lactation.

DOSAGE
Use for nebulizer: for greater convenience or easier use the product is contained in a plastic nebulizer suitable for intranasal use. For maximum effectiveness, you must press the dispenser during an inhalation, after blowing your nose. The first blow reduces swelling in the lower parts of the nose. By repeating the operation after a few minutes' interval, the deeper mucous membranes are decongested in order to open the nasal sinuses. Repeat every 3-4 hours if necessary. Use of the dropper bottle: Instill 2 - 3 drops of solution in each of the nostrils, after blowing the nose, and making sure of the deep penetration of the product, possibly repeating the operation after about ten minutes. In any case, the treatment must not be continued for more than four days.

STORAGE
The bottle must be kept tightly closed and protected from light as prolonged exposure to air, metals or intense light causes oxidation and a certain loss of power. Solutions with an altered color, although harmless, must therefore be thrown away. Store at a temperature not exceeding 25 degrees C.

WARNINGS
Use with caution and in the opinion of the doctor due to the danger of urinary retention, in the elderly and in patients with prostatic hypertrophy. The use, especially if prolonged, of topical products can give rise to aphenomena of sensitization and cause undesirable effects; in this case it is necessary to interrupt the treatment and, if necessary, to institute a suitable therapy. In patients with cardiovascular diseases and especially in hypertensive patients, the use of nasal decongestants must in any case be subjected to the judgment of the doctor from time to time. The prolonged use of vasoconstrictors can alter the normal function of the mucous membrane of the nose and paranasal sinuses, also inducing addiction to the drug. Repeating applications for a long period of time can be harmful. It is recommended not to combine other vasoconstrictors such as nasal decongestants, by the oral or nasal route, due to the risk of vasoconstriction. Children are more sensitive to the systemic effects of sympathomimetic vasoconstrictors, therefore the product should be kept out of their reach as accidental ingestion can cause severe central nervous system depression with strong sedation. Benzalkonium chloride (BAC) contained as an active ingredient in NTR, especially when used for long periods, can cause swelling of the nasal mucosa. If such a reaction is suspected (continuously congested nose), another nasal medicine without BAC should be used if possible. If such a nasal medicine without BAC is not available, another pharmaceutical form should be considered. It can cause bronchospasm. Nebulizer: if the bottle is new, press the dispenser two-three times without introducing into the fillers. Dropper bottle: to open the bottle it is necessary to press and unscrew at the same time. It is advisable to place the bottle on a base; to close the bottle screw normally; for subsequent use, repeat the procedure. The container is made of latex rubber. It can cause severe allergic reactions.

INTERACTIONS
An enhancement of the effect of phenylephrine may occur with antihypertensive drugs.

SIDE EFFECTS
The product can locally determine phenomena of sensitization and congestion of the rebound mucous membranes. For rapid absorption of phenylephrine through the inflamed mucous membranes, systemic effects may occur consisting of arterial hypertension, reflex bradycardia, headache, urination disturbances. Reporting of suspected adverse reactions The reporting of suspected adverse reactions that occur after the authorization of the drug is important, as it allows continuous monitoring of the benefit / risk ratio of the drug. Report any suspected adverse reactions via the national reporting system.

PREGNANCY AND BREASTFEEDING
Do not use during pregnancy and lactation.