Lasonil Anti-inflammatory and Antirheumatic 220 mg Naproxen Sodium 12 Tablets

Film-coated tablets containing naproxen sodium.

Therapeutic indications

Lasonil anti-inflammatory and antirheumatic is used for the symptomatic treatment of headache, back pain, joint and muscle pain, toothache and colds. It is also indicated against menstrual pains and minor pains in arthritis.

Dosage and posology

The quantity of Lasonil Anti-inflammatory and antirheumatic is for adults and adolescents over 16 years of 1 tablet every 8-12 hours. You may benefit most by starting with 2 tablets followed by 1 tablet every 12 hours, as needed. Use the lowest effective dose, particularly in elderly patients. The maximum daily dose is 3 tablets.

When and how long to take Lasonil tablets: Do not use for more than 7 days for symptomatic pain relief and for more than 3 days for colds without medical supervision. Consult your doctor if the disorder occurs repeatedly or if you have noticed any recent changes in its characteristics. Take this medicine on a full stomach. Swallow the tablets whole, accompanying them with a glass of water or other drink.

Overdose

In case of accidental ingestion / intake of an excessive dose of Lasonil Anti-inflammatory and Antirheumatic, notify your doctor immediately or go to the nearest hospital. If in any doubt, ask your doctor or pharmacist. Dizziness, drowsiness, heartburn, epigastric pain, digestive disturbances, nausea and vomiting, transient changes in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea and disorientation may occur as signs of overdose. Seizures have been reported in some patients but it is unclear whether these were related to naproxen overdose. A few cases of reversible acute renal failure have been described.

Contraindications

When it should not be used:

• Hypersensitivity to the active substance, to other closely related substances from a chemical point of view or to any of the excipients.
• History of asthma, urticaria or allergic-type reactions following the intake of acetylsalicylic acid or other analgesics, antipyretics, non-steroidal anti-inflammatory drugs.
• Severe renal insufficiency (creatinine clearance less than 20 ml / min)
• Severe heart failure
• Cirrhosis of the liver and severe hepatitis
• During intensive therapy with diuretics
• Gastric and duodenal ulcer
• Subjects with ongoing bleeding or at risk of bleeding
• During treatment with anticoagulants as it synergizes their action
• Pregnancy and breastfeeding
• Adolescents under the age of 16
• History of gastrointestinal bleeding or perforation related to previous active treatments or history of recurrent peptic ulcer / haemorrhage (two or more distinct episodes of proven ulceration or bleeding).

Side effects

Like all medicines, the anti-inflammatory and antirheumatic Lasonil can cause side effects, although not everybody gets them. The side effects seen with naproxen are generally common to other analgesics, antipyretics, non-steroidal anti-inflammatory drugs. The most commonly observed adverse events are gastrointestinal in nature. Peptic ulcers, gastrointestinal perforation or bleeding, sometimes fatal, may occur, particularly in the elderly. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn's disease have been reported following administration of anti-inflammatory and antirheumatic Lasonil. Gastritis was observed less frequently. Edema, hypertension and heart failure have been reported in association with NSAID treatment. Bullous reactions including Stevens Johnson syndrome and toxic epidermal necrolysis have occurred very rarely. Medicines such as anti-inflammatory and antirheumatic Lasonil may be associated with a modest increased risk of heart attack ('myocardial infarction') or stroke. Lasonil anti-inflammatory and antirheumatic causes a modest, transient, dose-dependent increase in bleeding time. However, these values often do not exceed the upper limit of the reference range.

Pregnancy and breastfeeding

Ask your doctor or pharmacist for advice before taking any medicine. Lasonil anti-inflammatory and antirheumatic should not be used during pregnancy and breastfeeding. Its use should also be avoided if you suspect a pregnancy or wish to plan a maternity leave.

Special warnings

It is important to know that when it can only be used after consulting your doctor Lasonil anti-inflammatory and antirheumatic should not be used in adolescents under 16 years. Medicines such as anti-inflammatory and antirheumatic Lasonil may be associated with a modest increased risk of heart attack ('myocardial infarction') or stroke. Any risk is more likely with high doses and prolonged treatments. Do not exceed the recommended dose or duration of treatment (7 days for symptomatic pain relief and 3 days for colds).

If you have heart problems or a history of stroke or if you think you may be at risk for these conditions (e.g. if you have high blood pressure, diabetes or high cholesterol or smoking) you should discuss your treatment with your doctor or pharmacist. Analgesics, antipyretics, non-steroidal anti-inflammatory drugs can cause water retention which rarely, especially in elderly patients, can precipitate congestive heart failure. Analgesics, antipyretics, non-steroidal anti-inflammatory drugs can cause hypersensitivity reactions, potentially fatal, including those of the anaphylactic (anaphylactoid) type, even in subjects with no history of hypersensitivity following exposure to this type of drug. The risk of hypersensitivity reactions after taking naproxen is greater in subjects who have experienced such reactions after the use of other analgesics, antipyretics, non-steroidal anti-inflammatory drugs (see: When it should not be used). After administration of analgesics, antipyretics, non-steroidal anti-inflammatory drugs, worsening of asthma is possible. The product is not indicated for pain in the gastrointestinal tract.

Expiry and retention

See the expiry date printed on the package. The expiry date refers to the product in intact packaging, correctly stored. The expiry date refers to the last day of the month. Store in the original package to protect from light. Keep this medicine out of the reach and sight of children. It is important that you always have the information about the medicine available, so keep both the box and the package leaflet. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to throw away any medications you no longer use. This will help protect the environment.

Warning: do not use the medicine after the expiry date shown on the package.

Composition

One tablet contains:

Active principle

Naproxen sodium 220 mg (equivalent to 200 mg of naproxen.)

Excipients

Microcrystalline cellulose, povidone K 30, talc, magnesium stearate; film coating: Opadry Blue YS 1-4215.