Kofidec Flu And Oral Cold Polv 10 Bust 4g Limon

Powder for oral solution with paracetamol, ascorbic acid and phenylephrine hydrochloride.

Therapeutic indications

Kofidec Fever and Cold is a symptomatic treatment of flu, cold and related feverish and painful states, with a decongestant action on the upper upper airways.

Dosage and Posology

Adults and children over 12 years: 1 sachet every 4-6 hours and up to a maximum of 3 sachets in 24 hours. Dissolve 1 sachet in half a glass of very hot water and, if desired, dilute with cold water to cool and sweeten as desired.

Overdose

At the recommended doses, or even if the entire pack is taken, no symptoms of paracetamol overdose should appear. However, in the case of ingestion of very high doses of paracetamol (greater than 15 g), the most commonly encountered complication is liver damage, which usually occurs 2-4 days after intake. The early symptoms are nausea, vomiting and abdominal pain: the appropriate therapy recommended is gastric lavage using specific antidotes such as acetylcysteine or methionine. More than 10 hours after ingestion, a haemoperfusion may be necessary.

Other symptoms of overdose are caused by phenylephrine and are manifested by irritability, headache and increased blood pressure.

Contraindications

• Children under the age of 12.
• Hypersensitivity to the active substances or to any of the excipients.
• Patients taking beta-blockers, monoamine oxidase inhibitors and tricyclic antidepressants.
• Patients suffering from renal insufficiency, diabetes, hyperthyroidism, hypertension and cardiovascular diseases.

Side effects

Skin reactions of various types and severities have been reported with the use of paracetamol, including cases of erythema multiforme, Stevens Johnson syndrome and epidermal necrolysis. Hypersensitivity reactions such as angioedema, laryngeal edema, anaphylactic shock have been reported. In addition, the following undesirable effects have been reported: thrombocytopenia, leukopenia, anemia, agranulocytosis, liver function abnormalities and hepatitis, renal changes (acute renal failure, interstitial nephritis, haematuria, anuria), gastrointestinal reactions and dizziness. With sympathomimetics (phenylephrine) skin irritation, tachycardia, hypertension and much more rarely nausea, vomiting or anorexia may occur occasionally.

Pregnancy and breastfeeding

Use during pregnancy is not contraindicated but requires caution; the administration of the preparation during pregnancy and lactation must take place under the direct supervision of the doctor and in case of real need.

Special warnings

The hepatotoxic effect of paracetamol can be enhanced by taking other drugs active on the liver. Use with extreme caution and under strict control during chronic treatment with drugs that can lead to the induction of hepatic monooxygenases or in case of exposure to substances that can have this effect (for example rifampicin, cimetidine, antiepileptics such as glutethimide, phenobarbital, carbamazepine). Paracetamol increases the half-life of chloramphenicol. The product taken in high doses can 'potentiate the effect of coumarin anticoagulants. Phenylephrine can antagonize the effect of beta-blocking and antihypertensive drugs and can enhance the action of monoamine oxidase inhibitors. Interference with some laboratory tests The administration of paracetamol can interfere with the determination of uric acid (by the phosphotungstic acid method) and with that of blood glucose (by the glucose-oxidase-peroxidase method).

During treatment with paracetamol, before taking any other drug check that it does not contain the same active ingredient, as if paracetamol is taken in high doses, serious adverse reactions can occur. Paracetamol products should be administered with caution to patients with mild to moderate hepatocellular insufficiency (including Gilbert's syndrome), severe hepatic insufficiency, acute hepatitis, concomitant treatment with drugs that impair liver function, glucose-6- deficiency phosphate dehydrogenase, haemolytic anemia. Instruct the patient to contact the physician before combining any other medication. The use of the product is not recommended if the patient is being treated with anti-inflammatories. Do not administer for more than 3 consecutive days without consulting your doctor. Contains sucrose: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.

Expiration and retention

Store at a temperature below 25 degrees ° C.

Composition

Each sachet of Kofidec Fever and Cold contains:

Active principles

Paracetamol 600 mg, ascorbic acid 40 mg and phenylephrine hydrochloride 10 mg.

Excipients

Sucrose, anhydrous citric acid, sodium citrate, corn starch, anhydrous silica colloidal, sodium cyclamate, sodium saccharin, lemon flavoring, honey flavoring, caramel flavoring.